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Does Weight
Affect Our Risk of Cancer?
Karen Collins, MS, RD, CDN
American Institute for Cancer Research
You've heard that skyrocketing obesity
is increasing our risk of heart disease and diabetes. A new study of more
than 900,000 American adults reports that cancer is also related to excess
weight. After following people for 16 years, researchers estimate that current
patterns of overweight and obesity in the U.S. could account for 14 percent
of all cancer deaths in men and 20 percent of those in women.
This research, reported in the New England Journal of Medicine,
demonstrates that as our weight increases beyond a healthy range, so does
our risk of many types of cancer. Looking at the overall risk of cancer death,
the lowest level of obesity raises risk nine percent in men and 23 percent
in women. More severe obesity raises that risk much higher: 20 to 52 percent
in men and 32 to 62 percent in women. Overweight and obesity are most strongly
related to risk of death from cancers of the colon, liver, gallbladder,
pancreas, kidney, prostate, breast, uterus, cervix and ovaries.
The links between overweight and overall risk of cancer, as well as the
identification of specific cancers that are weight-related, have been reported
in previous research. A Swedish study published in the journal Cancer
Causes and Control found about 33 percent greater cancer incidence among
the obese than among those of normal weight. A few years earlier, a landmark
report on diet and cancer risk by the American Institute for Cancer Research
(AICR) attributed certain cancers to obesity: 15 to 30 percent of uterine
cancer deaths, 11 to 30 percent of breast cancer cases and 25 to 33 percent
of kidney cancer occurrence.
In comparing these results with those of other reports, we need to note
that the statistics in the most recent study refer to death rates from various
cancers. That means we are seeing the total effect of weight on the development
of various cancers, as well as any impact on survival and even diagnosis.
Both the AICR report and a new report on cancer from the World Health Organization
(WHO) agree that the international epidemic of obesity is a major part of
today's cancer risk. Both reports identify cancers of the colon, kidney,
uterus and breast (after menopause) as obesity-related, and WHO adds esophageal
cancer to the list.
In the most recent study, researchers adjusted statistics to account for
the influence of various factors on colon cancer, including fat and vegetable
consumption as well as physical activity. Interpreting the results, they
say that, with all three factors being equal, excess weight raises risk of
death from cancer from 9 to 62 percent. But in real life, all these factors
could be related, because eating more vegetables or less fat, and exercising
regularly may be part of how someone reaches or maintains a healthy weight.
Since smoking has such strong cancer-causing effects, despite its association
with lower weight, it can confuse the relationship of weight to cancer risk.
So in trying to assess how many cancer deaths are truly related to excess
weight, researchers used the proportion of cancer deaths linked to weight
among those who have never smoked. On this basis, they concluded that current
patterns of overweight and obesity in the United States could account for
14 percent of all deaths from cancer in men and 20 percent of those in women.
That translates to 90,000 deaths a year that could be prevented if people
maintained healthy weights.
The American Institute for Cancer Research (AICR) offers
a Nutrition Hotline (1-800-843-8114) 9 a.m. to 5 p.m. ET Monday-Friday. This
free service allows you to ask questions about diet, nutrition and cancer.
A registered dietitian will return your call, usually within 48 hours. AICR
is the only major cancer charity focusing exclusively on the link between
diet, nutrition and cancer. The Institute provides education programs that
help millions of Americans learn to make changes for lower cancer risk.
AICR also supports innovative research in cancer prevention and treatment
at universities, hospitals and research centers across the U.S. The Institute
has provided more than $65 million in funding for research in diet, nutrition
and cancer. AICR’s Web address is www.aicr.org. AICR is a member of the
World Cancer Research Fund International.
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